Comparative efficacy and safety of two different molecular weight (MW) hyaluronans F60027 and Hylan G-F20 in symptomatic osteoarthritis of the knee (KOA). Results of a non-inferiority, prospective, randomised, controlled trial
نویسندگان
چکیده
1Rheumatology Department, Saint-Antoine Hospital, Paris, France; 2Clinical Department, Institut de Recherche Pierre Fabre, Ramonville, France; 3Rheumatology Department, Erasmus Hospital, Bruxelles, Belgium; 4Rheumatology Department, Nzoz “Nasz Lekarz”, Torun, Poland; 5Department of Orthopaedics, 2nd Medical Faculty, Charles University, Prague, Czech Republic; 6 Department of Traumatology and Orthopaedics Tartu University Hospital, OCRC, Tartu, Estonia. . Abstract Objectives To compare the efficacy and safety of a “medium” molecular weight (MW) hyaluronan product (F60027, Structovial®) with a “high” MW (Hylan G-F20, Synvisc®).
منابع مشابه
A randomised, double-blind, controlled trial comparing two intra-articular hyaluronic acid preparations differing by their molecular weight in symptomatic knee osteoarthritis
OBJECTIVES To compare the effects of an intermediate molecular weight (MW) intra-articular hyaluronic acid (HA) with a low MW product on knee osteoarthritis (OA) symptoms. METHODS Patients with symptomatic knee OA were enrolled inarandomised, controlled, double-blind, parallel-group, non-inferiority trial with the possibility to shift to superiority. Patients were randomised to GO-ON(MW 800-1...
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OBJECTIVES The primary objective was to compare a single, 6 ml, intra-articular injection of hylan G-F 20 with placebo in patients with symptomatic knee osteoarthritis. The safety of a repeat injection of hylan G-F 20 was also assessed. METHODS Patients with primary osteoarthritis knee pain were randomly assigned to arthrocentesis plus a 6 ml intra-articular injection of either hylan G-F 20 o...
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